Opioid withdrawal symptoms are uncomfortable, but there are opioid withdrawal treatments your medical provider can prescribe to help relieve these symptoms. Clonidine helps reduce anxiety, irritability, muscle aches, sweating, and runny nose, and hydroxyzine (Atarax) can also help with anxiety and insomnia. Tizanidine (Zanaflex) helps reduce muscle spasms. Ondansetron (Zofran) relieves symptoms of nausea and vomiting. Loperamide (Imodium) helps relieve diarrhea. Bentyl helps relieve gastrointestinal (GI) symptoms, especially abdominal cramping. And lastly, once you start the induction and stabilization phase with buprenorphine/naloxone (Suboxone), you will experience significant reduction and relief from withdrawal symptoms.