Summary: Opioid addiction is a significant health threat. However, not all opioids are equally addictive. It means that making changes to the chemical structures of existing opioids may make them less addictive. Researchers think that they have found a way to do so. It appears that introducing the fluorine atom to various opioids may make them less addictive and yet ensure that they work well at the site of injury.

Opioid epidemics are showing no signs of receding. However, on the other side, we cannot negate that opioids are among the best painkillers. It means that giving up opioid use altogether may cause specific issues. Doctors may find it hard to manage moderate to severe pain without opioids. The Lives of those living with chronic pain may become miserable.

On the other hand, it has long been known that various opioids differ significantly, and some of them are not addictive at all. For example, codeine used to treat pain and dry cough has a low probability of causing addiction. Likewise, the anti-diarrheal drug loperamide does not cause addiction at all. Finally, even the synthetic opioid painkiller tramadol does not appear to cause addiction. Hence, why not try to create potent opioid painkillers that might lack any addictive effect?

There is a need to make some minor changes in the existing opioids so that they stop penetrating the blood-brain barrier and causing euphoria. This is possible, though challenging. However, considering the rise in opioid overdose and painkiller abuse, it is also a need of time. Moreover, opioids are almost irreplaceable in many clinical conditions.

Of course, chemists could have done it a long time back if it was that simple. Nonetheless, in recent years, there have been many technological advances. Thus, for example, computational chemistry has provided greater power to chemists.

Understanding Opioid Chemistry

Though there are many types of opioids, as one can see in the image above, they share some basic structures. However, though they have minor differences, they result in entirely different chemical and even biological properties.

Of course, one of the issues is that one cannot make significant structural changes to opioids, as it may result in reduced efficacy. However, suppose we want to reduce addictive effects of opioids. In that case, we need to find ways of making more significant changes to opioids and yet ensuring that their pain-killing effect is preserved.

This subject is not new. There are already some opioids that have a pretty different chemical structure when compared to morphine or other classical opioids. One such example is fentanyl.

Studies show that one of the ways in which opioids work is by becoming positively charged upon coming in contact with body fluids.

This positive charge helps opioids to bind on the target site. However, the problem with the existing opioids is that they become positively charged in all body fluids, in different organs, including the brain. So, it means that if we could find some way of preventing it or ensure that it only becomes charged at specific sites, this can help overcome addiction and many side effects of opioids.

Making Opioids Less Addictive

Researchers think it is necessary to change the opioid structure so that they become positively charged only in high-acidity environments. Studies show that injured tissues or inflammation sites have higher acidity than other body parts due to lactic acid accumulation. It means that any opioid requiring a greater acidic environment for activation will have a greater effect on the target site and will be less likely to cause euphoria.

Researchers have found this is possible, especially with the introduction of a fluorine (F) atom near the nitrogen, in the amine group of fentanyl. This will ensure that fentanyl remains less active in various body fluids but gains a higher activity level at the sites of inflammation and pain. What is exciting about this finding is that new studies show that introducing the fluorine molecule into morphine may also alter its characteristics. Thus, morphine will need a bit higher acidity to become active and start acting. This will help produce morphine that is more active in injured tissues, and thus less active in the brain and other sites, and hence less likely to cause addiction.

Now-a-days, the opioid treatment programs have started to utilize suboxone in their treatment, which is another potential medication. Researchers think they can explore an approach to alter the working of oxycodone and hydrocodone further. However, to date, this approach has only been tested in labs and appears to work. Thus, now there is a need to evaluate it in clinical trials.

Summary: More than 85% of US adults report drinking alcohol, and data suggests that about 25% of the population engages in binge drinking. Additionally, it appears that about 6% of adults are addicted to alcohol. Prolonged alcohol abuse causes premature death due to many causes like a motor vehicle accident or liver disease. The new study suggests that Covid-19 intake has increased alcohol-related deaths. This may be due to increased mental stress, work-from-home culture, and other reasons.

Alcohol consumption is pretty common and is a part of western culture. Thus, no surprise that all reputed localities are laced with pubs, bars, and more. It is common for people to have a drink after a hard working day. A drink helps relax and communicate and is an enjoyable activity. Though most people know that excessive alcohol can harm health, many do not realize the scale of the problem. This may explain the rate of increasing deaths due to alcohol addiction.

US data shows that about 85% of all adults drink alcohol. However, casual alcohol drinking is not an issue. But US statistics are alarming as they show that one-fourth of US adults engage in binge drinking. As a result, one-fourth of the population is at the risk of developing excessive alcohol consumption-related disorders and premature death.

Studies also suggest that about 7% of adults in the US are living with alcohol addiction. An estimated 14.5 million people older than 12 years of age have alcohol abuse disorder (AUD). AUD or alcohol addiction is a disease that must be treated; else, it may harm health severely. But, regretfully, only about 10% of those living with AUD or alcohol addiction seek treatment for the condition. Instead of seeking for their alcohol addiction treatment, people are more likely to seek treatment for health disorders caused by excessive drinking.

Alcohol addiction or excessive drinking may cause premature death for many reasons, like motor vehicle accidents, homicides, alcohol overdose, suicides, liver disease, kidney failure, and cancer. What is worrisome is that people of working age are more likely to consume alcohol excessively. Excessive alcohol use now causes more than 140,000 deaths in the US annually. It means about one in ten deaths among working-age adults is due to excessive alcohol use.

What the new studies add to the current understanding of alcohol addiction is that excessive alcohol use-related deaths are rising. It confirms the worrisome trend. Although in the last few decades, there is not much change in the rate of alcohol consumption, but more people are engaging in binge drinking.

The study was especially done by keeping in mind the impact of the Covid-19 epidemic on alcohol consumption habits. Covid-19 caused significant stress. Additionally, more people started working from home. The study confirmed that this resulted in excessive alcohol intake. This resulted in a slight increase in alcohol-related deaths in the US from 2.8% in 2019 to 3% in 2020.

Although data may show only a minor increase in alcohol-related deaths, nonetheless, the numbers are significant. Moreover, it shows an upward trend, something that cannot be neglected.

Alcohol consumption in moderation does pose many health threats. However, binge drinking (four or more drinks) or heavy drinking (eight or more drinks) can significantly harm health. To prevent deaths associated with excessive alcohol consumption, people should seek attention for alcohol use disorder (AUD) and not for health complications arising from alcohol addiction.

Treating alcohol addiction or AUD is different from treating drug addiction. AUD is often the result of years of alcohol use. Quite often, a person may not even realize that he or she is living with the condition. Most such individuals start by drinking alcohol in moderate amounts. However, with time or due to stress, they might begin abusing alcohol.

Summary: Those living with opioid use disorder are generally hesitant to seek medical help. However, covid-19 epidemic has only made things worse. Thus, policymakers legalized providing medical care to those living with OUD via telehealth. However, there have been some concerns regarding the decision. The new study shows that telehealth is beneficial for those living with OUD and is associated with a reduced risk of overdose events. This underscores the importance of telehealth in providing treatment and care for opioid addiction treatment.

The scale and extent of covid-19 pandemic took everyone by surprise. The world was not ready for the pandemic. This created many challenges. It made providing medical help to a specific group of patients more difficult. Moreover, due to covid-19, people got confined to homes and traveled less often. It also means that covid-19 related restrictions created a barrier to seeking medical help.

 

It is no secret the those living with opioid use disorder (OUD) are less likely to seek medical help. There are many reasons, from social stigma to disbelief in the system. For such individuals, things became even more difficult during the pandemic times.

Fortunately, US policymakers realized this challenge faced by people living with OUD and legalized telehealth for OUD. It means that for the first time, doctors could legally prescribe opioids used to manage OUD without seeing a patient. However, this change in policy was not well received by everyone. Many were skeptical of such a change and worried that it might even make the ongoing opioid overdose epidemic worst, as opioids would become more accessible for many.

Fortunately, a new study shows that these policy changes have been beneficial and resulted in reduced risk of overdose. The study was carried out by researchers from CDC, NIDA, NIH, and CMS. The results of the study were published in the journal JAMA Psychiatry.

In the study, researchers analyzed the data of 175,778 Medicare beneficiaries from September 2018 to February 2021. They focused on analyzing the events of an overdose in those who received medications for opioid use disorder (MOUD) through telehealth during the pandemic.

They had several interesting findings:

• They found that there was a sudden upsurge in people seeking telehealth services for OUD. Thus, these numbers increased from 0.6% to 19.6% during the pandemic.
• Interestingly, they also found that people receiving telehealth care were more likely to receive MOUD, which was 12.6% for telehealth. In contrast, these numbers were 10.8% for those who visited the doctors.
• Telehealth services had many positive effects on patient care. Thus, those treated for OUD were more likely to stick to their treatment. In addition, patients were less likely to overdose on their drugs.

Researchers say that their findings show that telehealth services helped overcome the barrier to medical care for addiction. This barrier to seeking medical help is among the most important reasons why many do not seek medical help. Lack of treatment and support naturally means a greater risk of a drug overdose. 

Researchers say that there is clear evidence of the benefit of telehealth. It is not just good for patients; it can be lifesaving for many. In addition, it is clear that telehealth can have many long-term positive effects on patients.

The study also noted some disparities due to an existing digital divide. Thus, non-Hispanic black people were less likely to seek tele help. Therefore, countering this digital divide is vital for fully exploiting the benefits of telehealth.

Researchers say that though the covid-19 pandemic has created many challenges for the healthcare system, it has also provided opportunities for investigating various ways of providing healthcare.

To sum up, this study is supportive of telehealth for OUD, and it shows that these services must be continued even in the post-pandemic era. 

Summary: Since Purdue Pharma, the manufacturer of OxyContin, agreed to close their company by paying $8 billion in compensation, several other investigations and legal battles have begun. The Justice Department has filed a legal case against Walmart retail and wholesale for dispensing opioids without taking a good look at prescriptions, thus blaming it for having played a role in the opioid epidemic. However, Walmart disagreed, saying it could not come in between the doctor and patients and reported suspicious prescriptions to DEA. Ultimately, such legal battles might also impact patients who need opioids to control their chronic pains.

Since the opioid epidemic has come into the limelight, things have been changing fast. New regulations and prescription guidelines have been introduced by different stakeholders. However, due to pressures from various groups, multiple investigations have also begun, and so has the blame game.

Thus, the Department of Justice now alleges that Walmart has played a significant role in the opioid crisis. Moreover, the department says that Walmart’s retail chain and distribution unit are to be blamed for the epidemic.

The Justice Department says that Walmart did not pay adequate attention to many things, and thus they broke the law. They continued to dispense opioids to hundreds and thousands of people with invalid prescriptions and failed to report suspicious opioid orders. The department has filed a legal case against Walmart in the US District Court for the District of Delaware.

The department says that as the largest pharmacy chain, it has the means to prevent violations. However, they did not take appropriate measures.

However, Walmart has blasted the Justice Department for inventing some kinds of theories. They say that doctors prescribed, and Walmart pharmacies were bound to fulfill prescriptions. Therefore, Walmart cannot come in between the doctor and the patient.

However, the Justice Department did not agree with Walmart’s explanation, saying that Walmart knew that many of those prescriptions were not for true medical purposes. Not only that, but the Justice Department also blames Walmart for failing to report these issues to the Drug Enforcement Agency (DEA).

However, Walmart did not agree with most of this, as it says there has been a failure at the end of regulatory agencies, including DEA. They say they have empowered their pharmacists to refuse to fill prescriptions if they find them doubtful or if the opioids were not prescribed for the right reasons. On its end, Walmart claims it has sent tens of thousands of investigative leads and blocked thousands of questionable doctors. However, DEA failed to act on these leads.

The Justice Department has been pursuing all the companies it deems responsible for the opioid epidemic. However, things changed after Purdue Pharma, the maker of OxyContin, pleaded guilty and agreed to pay more than $8 billion to close the company.

However, all these legal tussles and blame games are not good news for people living with chronic pain and struggling with opioid addiction. It means those who need opioids for chronic pain treatment would now struggle to get prescription refills and those seeking opioid addiction treatment may face difficulty as well.

There is no doubt that doctors and pharmacists should take extra care when prescribing and dispensing controlled substances. However, abuse of specific medications by some individuals should not result in the inaccessibility of these beneficial remedies for those who need them most, including those seeking chronic pain treatment or opioid addiction treatment.

It is true that the opioid epidemic has caused many issues. However, if opioids become difficult to get, many of those addicted to opioids will start using other substances. However, when it comes to people living with chronic pains, they have limited options, as in many cases, opioids are irreplaceable. Thus, if the industry becomes too hesitant to produce, pharmacies reluctant to dispense, and doctors unwilling to prescribe, millions of people would suffer from pain and other severe health issues.

Summary: Opioid crisis and opiate abuse have only worsened in recent years, despite declining rates of opioid prescription. It is no secret that many people living with OUD are not seeking treatment. There are many causes for people not seeking treatment, like clinics not taking new patients, or many are just hesitant to seek treatment. However, telemedicine now offers hope. Doctors can not only treat OUD through online apps or platforms but also prescribe drugs like suboxone, which is a combination of buprenorphine and naloxone.

It is no secret that there are many reasons why so many people are not getting OUD treatment. One of the reasons is that there are just not enough clinics and specialists to treat the condition. In addition, many clinics are not taking new patients, and there are long waiting times.

Another, perhaps, even more significant reason is that those living with any kind of addiction do not want to go to clinics. There is much hesitance. They think that others would not understand their problem or simply do not want to travel, seek help, and more.

However, what if we said that now you can get opioid treatment programs online and prescription for medications? Finally, many states have approved the use of telemedicine in treating OUD. It is the right step, considering the scale of the problem.

Moreover, for most people living with opioid addiction, privacy is also a significant reason for not seeking help. Now they can expect to get treatment in the privacy of their home and even expect to get prescription medication.

Many clinics have now launched online OUD treatment services, which are completely legal. But, of course, there are some requirements to be fulfilled. For example, DEA has made it necessary that patients should undergo live video interviews with healthcare providers and not consult via chat. These limitations are just for the first time, as later, one can keep in touch with the clinics through other means.

Currently, a drug called suboxone is approved for treating addiction through telemedicine. It means that doctors can prescribe this to those living with OUD without the need to visit a clinic. It is among the most effective drugs to treat OUD, and it is a combination of buprenorphine and naloxone.

Suboxone is a very interesting medication and quite effective due to its unique mode of action. For example, buprenorphine works almost in the same way on opioid receptors as oxycodone. However, its activity is much less. Naloxone, on the other hand, blocks the effects of opioids.

Generally, naloxone is not used along with opioids like medications due to the risk of some severe side effects. However, it seems that combining it with buprenorphine is safe and good. Such a combination help overcome withdrawal syndrome quite effectively and, at the same time, block some of the unpleasant effects of prolonged opioid use. Hence, it is among the most effective ways to recover.

Online suboxone prescription is legal, but not in all states. Thus, if you are looking for a suboxone treatment option, you would need to check if online it is legal in your state. Of course, it is worth understanding that things are changing fast, and it is becoming legal in an increasing number of states. Thus, checking the latest information is always a good idea.

Of course, there are some other limitations of this kind of treatment. Besides the first online video interview, doctors would regularly ask you to get tested for opioid use. They would often send you a testing kit, and you will need to carry out the required tests, or else doctors can stop prescribing suboxone. These are some of DEA’s strict requirements, and everyone must stick to them.

Here it is vital to understand one more important thing; if suboxone online prescribing is legal in your state, it does not mean that just any doctor can prescribe it. Buprenorphine is still a controlled substance; thus, clinicians need to obtain a special waiver from the Substance Abuse and Mental Health Services Administration (SAMHSA).

Moreover, to avoid any pain killer addiction, there has to be a strict dosage prescription policy , both by the patient and the doctor.

Summary: TKA is a major surgical intervention requiring prolonged use of painkillers post-surgery. Additionally, doctors also need to use anxiolytics and antidepressants to manage emotional distress in many patients. A new study shows that those requiring psychotropics are also more likely to require longer opioid use due to a greater pain score.

 

Knee osteoarthritis, a common condition in the United States affecting millions of people, can be treated with various methods, including opioid addiction treatment. It is characterized by the degeneration of cartilage in the knee joint, leading to pain and disability that can significantly impact a person’s quality of life, making it difficult to perform everyday activities such as walking, climbing stairs, and participating in physical activities.

Total knee arthroplasty (TKA), also known as knee replacement surgery, is a common treatment option for individuals with severe knee osteoarthritis. TKA involves removing the damaged parts of the knee and replacing them with artificial components, which can significantly reduce pain and improve mobility. However, TKA is typically only recommended for patients who have not responded to less invasive treatments, such as physical therapy, weight management, and pain management.

TKA is a major surgical intervention. However, it also provides significant relief to the patient once the joint has healed after the surgery. In addition, TKA ultimately results in lower dependence on painkillers, as most are able to live without painkillers. Generally, patients need opioids for the first three months after the intervention. Opioids, though highly effective in controlling postoperative pain, are not an excellent choice. They slow down healing processes. Additionally, though minimal, but there is still a risk that prolonged opioid therapy in the post-surgical phase may increase the risk of opioid dependence in some.

However, it is worth understanding that pain is not the sole concern of those who undergo TKA. Most patients also require treatment for mental health issues, for emotional distress. Total knee arthroplasty (TKA) can also cause significant anxiety and depression in some patients. The reasons for this can be diverse and interrelated but generally stem from the patient’s concerns about the outcome of the surgery, the recovery process, and the ability to return to normal activities.

Chronic pain, which is a common symptom of knee osteoarthritis, can lead to depression and anxiety. In addition, the physical limitations imposed by the pain and disability associated with knee osteoarthritis can also contribute to feelings of hopelessness and depression.  All this means that doctors frequently use psychotropics in TKA patients to manage pain and mental health issues. Moreover, many patients report better pain relief when they are provided drugs like anxiolytics or antidepressants along with opioids.

However, now some researchers warn against the frequent use of anxiolytics or antidepressants in TKA patients. Since new studies show that using these drugs may result in longer opioid use in patients. Not only that the patients use opioids for longer, they even had higher pain scores when psychotropics were used along with opioids. Although, it does not seem to have any influence on readmission rates or emergency department visits.

It means that using psychotropics in TKA patients along with opioids has limited health benefits and must be used with great care. Overall, researchers found that patients on these medications require more aggressive pain control after surgery. Moreover, these issues were seen even in patients prescribed anxiolytics or antidepressants for other reasons, and they did not experience anxiety or depression. Of course, it is not possible to treat all the patients without these drugs. Nonetheless, the study shows that those living with mood disorders are more likely to experience prolonged post-TKA pain and recover slower.

It is our mission to bring real hope and transformational change to patients who would otherwise be consigned to a lifetime of medications, doctor’s visits, and suffering. We expose misaligned incentives and return the power of health to the individual. We believe empowered individuals change their communities. We use a combination of lifestyle intervention, medication management, and emerging scientific research to help our patients.  When you are ready or have questions, reach out.

The content provided herein is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. No information in this content should ever be considered as a substitute for advice from a healthcare professional, it is provided for thoughtful discussion, informational and educational purposes only.

Summary: Fibromyalgia is a common chronic disorder causing body aches, fatigue, tenderness in various body parts, depression, sleep disorders, and more. The condition is caused by certain changes in the brain that remain poorly understood by science. Doctors treat fibromyalgia using painkillers, antidepressants, and other medications, but the treatment is far from satisfactory. However, new studies suggest that psychedelics like psilocybin or LSD may help in chronic pain treatment, as they can help reset the brain, providing long-term relief in the condition.

Fibromyalgia is among the most complex disorders to diagnose and treat. Fibromyalgia causes widespread body aches. There are multiple areas of high pain sensitivity. Not only that, but it also causes fatigue, sleep disorders, depression, and more.

However, the condition is still poorly understood by science. That is why it remains a diagnosis of exclusion. Before confirming the diagnosis, doctors would generally exclude other well-known chronic health disorders causing similar symptoms like body aches and fatigue. Its diagnosis is mainly clinical, and there are no reliable biomarkers to confirm it. Nevertheless, it is among the common causes of chronic pain. What is worrisome is that its incidence is increasing.

There is no single drug therapy that would work for all. Thus, doctors would prescribe non-inflammatory drugs and anti-seizure medications, like gabapentin, and antidepressants, to treat the condition. However, the benefit from most of these drugs is far from satisfactory, and the risk of side effects from such treatments is high. Thus, there is a need to find safe medications to treat the condition.

In recent years, doctors have understood that fibromyalgia is caused by some brain changes causing hyperalgesia and fatigue. Thus, body tenderness in the condition is rather due to changes in the brain and not due to some local inflammation. Hence, it is vital to explore drug therapies that may help alter the brain’s working. Psychedelics are known to help reset the brain and provide prolonged benefits for many brain disorders. However, psychedelic therapy still remains largely experimental in various health disorders.

Now, one of the pharma startups has decided to explore the role of psychedelics in managing fibromyalgia. A California-based company called Tryp Therapeutics has partnered with the Chronic Pain & Fatigue Research Center at the University of Michigan Medical School for a phase 2 study regarding the use of psilocybin to treat fibromyalgia.

There are many reasons to consider psilocybin. It is the psychoactive compound found in “magic mushrooms” and is known to be relatively safe. Thus, researchers do not need to spend years generating pre-clinical data, and they also do not need to start with a phase 1 study, which mainly focuses on the safety of the compound and its humans. It is because there is already sufficient information about psilocybin, and its safety in humans is established to a degree. It has the potential of becoming the best treatment for fibromyalgia.

Of course, phase 2 studies are also about safety, but they are more extensive than phase 1 studies. Moreover, they also focus on efficacy at a safe time. Thus, the possibility of starting from the phase 2 study means much savings in both financial terms and timelines.

The company will test synthetic psilocybin. Early studies suggest that psilocybin can alter neuroplasticity, alter many neural networks, and cause long-term changes in brain function. Hence, it is likely that it may help reduce hyperalgesia of central origin often found in those with fibromyalgia.

Everyone is very excited about the study, as its success may change how fibromyalgia is managed and may even affect how chronic pain treatment, opioid addiction treatment and depression management is carried out. But, of course, these are still early days, as the company is still only getting ready to file for phase 2 trials. Such a trial needs to enroll a few hundred people. However, for the US FDA to approve the drug for medical use, there would be a need for a phase 3 trial, which is much more extensive.

So, sure, there is still a way to go. Nevertheless, the news is exciting, as pharma companies have started looking beyond traditional painkillers or antidepressants to manage such conditions. Moreover, there is limited evidence that antidepressants work for fibromyalgia.

Even more interesting is that other pharma companies have also started exploring the role of psychedelics in managing fibromyalgia. Thus, another company, Mind Medicine, has announced that they are beginning their investigation regarding the use of LSD to treat chronic pain syndrome and get cluster headache relief.

To date, LSD and psilocybin are classified as Schedule 1 controlled substances; hence, they are not approved for any medical use. However, these studies may change all that.

Summary: Vaping was promoted as a safe alternative to tobacco smoking. However, experience shows that it is far from true. Vaping has its own set of health risks. For example, it is known to cause severe effects on lungs leading to fatal outcomes. However, now, new studies suggest that it may be addictive, increase the risk of addiction to other substances, and may have many other longer-term adverse consequences for wellbeing. The new study suggests that various vaping juices may cause increased expression of inflammatory mediators in multiple organs, including the brain, heart, lung, and colon. Moreover, the study also found that the adverse effects of different flavors differ.

Treating one kind of addiction with another less dangerous addiction is not an ideal solution to the problem. Vaping has picked up in recent years. Initially, many promoted it as a way of overcoming tobacco addiction.

However, things are changing fast, and many people vape who never used tobacco. It means that vaping itself is emerging as a significant problem. Moreover, studies show that it is not as safe as imagined earlier and may cause some unique health issues. Data regarding its adverse health effects is still emerging.

What is worrisome is that vaping is a pastime activity of young minds. Most people vaping is between the ages of 18-24. It is also worth understanding that vaping has only picked up in the last few years.

Therefore, it may even become a significant health concern if timely measures are not taken. Therefore, there is an urgent need to raise awareness regarding the health risks associated with vaping. Furthermore, considering how fast people accept vaping and get addicted to it, most people may start vaping in a decade.

Vaping may alter inflammatory responses of the brain, heart, lungs, and colon

It is now known that vaping causes severe and life-threatening lung disease in some. It is already causing a few deaths each year. However, these findings are insufficient to raise awareness regarding the health risks of vaping addiction, as people see it as something uncommon. Most people see vaping-related lung disease as a rare disorder affecting a few.

However, people do not realize that vaping may have many long-term ill effects on health.

Studying the ill effects of vaping on health is more challenging than understanding the risk of tobacco addiction. Unlike cigarettes that use various tobacco strains with varying degrees of nicotine, vaping uses many different kinds of vape juices with quite different chemical compositions.

It means that vaping one kind of liquid may have a certain set of side effects. While using another type of vaping juice may have completely distinct side effects.

The new study published in the journal eLife explored the ill effects of various commonly available vaping flavors or some of the leading vaping devices like JUUL.

In the study, researchers were especially amazed by the significant elevation of inflammatory markers that are associated with poor brain health and an even higher risk of neurodegenerative disorders. Experts noted that vaping fluids caused changes in gene expression in the brain. They found that this effect is especially marked in the nucleus accumbens, a brain region that plays a vital role in the reward pathway.

These findings are concerning, as they suggest that vaping may also increase the dangers of mental health disorders. Thus, it may increase the risk of anxiety, depression, and more. In addition, it may also cause behavioral changes, increasing the risk of addictive behavior. This may also increase a person’s risk of substance abuse and addiction.

Similarly, the authors of the study noted that certain vaping juices increase colon inflammation. However, these changes were seen after one month of regular vaping.

Similarly, vaping influences gene expression and increases inflammation of the lungs and even other body tissues.

Researchers also noticed that the inflammatory response of different organs differed to various vaping flavors. This is explained by the different chemical compositions of various vaping juices.

These findings are also relevant in the context of the covid-19 epidemic since the body of those addicted to vaping would respond differently to the infection.

It appears that apart from general immunity, every organ has its immune environment. Thus, these findings are disturbing, as they indicate that vaping may alter the immune responses of individual organs. It may have unpredictable ill effects on health, especially over the long term which form sufficient reasons to quit vaping.

Summary: Although it appears that Covid-19 is now almost over, experts warn that the US healthcare system is facing some other severe threats. It is expected that in coming years, inflation, shortage of nursing staff, and burnout among physicians will significantly affect the quality of healthcare in the US.

Though seasonal epidemics are not rare, the Covid-19 pandemic took the world by storm and surprise. It dominated daily life for a couple of years before mass vaccination, and the emergence of herd immunity led to its decline.

We are already into the third year of the pandemic, and it is far from over. Nonetheless, most experts agree that the peak is now over. It is now more likely to become a low-level health threat, like the flu or other seasonal infections. It means that worse is behind us.

Though disaster predictions are often wrong, they have their role. These predictions do not create panic but rather prepare people for the worse. A well-prepared person or society is more likely to steer through the storm.

Researchers think that when it comes to healthcare in the US, there are a few things that everyone should be worried about. However, the US is facing certain threats that may cause significant physical and mental health issues soon.

Untamed inflation

Many economists have already warned that trillions spent to counter Covid-19 may cause severe inflation. However, most of those models did not take into consideration other issues that were not visible on the horizon at that time, like the war in Ukraine and rising oil prices. Together these factors can drive inflation to an all-time high.

These issues can significantly limit the ability of the federal government to fix the problems faced by the healthcare system. Researchers warn that healthcare costs can become exorbitantly high in the near future. It is worth understanding that these costs do not rise daily and are fixed for a few years. Hence, if the cost of living keeps rising, healthcare costs may suddenly rise. Moreover, insurers are planning to increase their premium in the coming year.

Nursing shortages

US data shows that the nation is going through a shortage of nurses, and as a result, delays in planned surgical procedures and other healthcare services are becoming all too common.
There are multiple reasons for these shortages. For example, one survey shows that one-third of RNs just want to change their current roles. Many of them plan to leave nursing altogether. Additionally, about one-fourth of baby boomer RNs are retiring within the year. These are highly trained nurses who would be challenging to replace.

It is expected that in the next year or two, the healthcare sector in the US will experience a severe shortage of nursing staff. Some experts warn that the shortage would be so acute that it would significantly affect the working of hospitals. This will result in a significant number of patients being turned away from hospitals.

Experts warn that it would be wrong to assume that such a problem can be resolved quickly. Though one can produce more nurses in a couple of years, it takes much longer to produce well-trained nurses. Most nurses acquire skills over years of practice

The burnout crisis

Innumerable studies are showing this problem among doctors. It seems that the burnout crisis is especially severe among doctors. The prevalence of burnout is much higher among doctors compared to other professions.

Further, it appears that the burnout crisis has been made worse by the Covid-19 pandemic due to emotional trauma. It seems that many healthcare workers have reached a boiling point.

Burnout crisis among doctors and shortage in nursing staff will significantly affect the healthcare quality in the US. Doctors are now rejecting the word burnout, instead calling it a “moral injury.” A pain caused to them due to their inability to provide excellent medical care. All this means that doctors are increasingly turning to private equity (PE) firms.

If these threats are not handled soon, they will have grave consequences for US healthcare in the short and long run.

It is our mission to bring real hope and transformational change to patients who would otherwise be consigned to a lifetime of medications, doctor’s visits, and suffering. We expose misaligned incentives and return the power of health to the individual. We believe empowered individuals change their communities. We use a combination of lifestyle intervention, medication management, and emerging scientific research to help our patients. When you are ready or have questions, reach out.

Medical Disclaimer: Keep in mind that the content provided is not direct medical advice for patient care, but is provided for thoughtful discussion.

Summary: Heave drinking, binge drinking, and AUD are significant social and health problems. Many people struggle to say no to alcohol despite realizing the ill effects of heavy drinking. Psychotherapy is one of the effective and safe ways to manage the condition, as it helps rewire the brain and alter the thinking pattern. Now a new study shows that using psilocybin along with psychotherapy may have much higher benefits. After such a treatment, people are almost twice more likely to abstain from alcohol and report a significant decline in cravings.

Alcohol is widely consumed in the US. About 80% of all adults drink alcohol now and then, and some of them consume it quite frequently. However, some people start engaging in excessive alcohol consumption, which is harmful to health.

According to the CDC, binge drinking is having four or more drinks on a single occasion. And heavy drinking means having eight or more drinks.

Excessive and irresponsible alcohol use is a significant problem in the US. Moreover, this problem is quite common in young adults. It is among the leading cause of death in young adults. AUD causes 140,000 deaths each year, and it also causes significant disability and economic harm.

Psilocybin is a psychedelic compound from magic mushrooms widely used for its trippy effect. It causes hallucinations. Yes, it remains a controversial compound for clinical use. It is still a substance of abuse, and FDA does not allow its clinical use. However, FDA allows its use for clinical studies.

Researchers have been experimenting with psychedelics for more than half a century to treat various mental health issues.

However, they have recently discovered how to use these agents safely and effectively. They understood that these agents are only suitable for use under medical supervision and for the short term. They work at lower dosages and are more effective when combined with psychotherapy.

When combined the psychotherapy, they help rewire the brain quickly. Their effect is unlike other medical drugs that take a long time to start acting and have a short-lasting action. Instead, psychedelics work fast and may provide long-lasting relief due to improved brain rewiring. They are especially good for managing mood disorders like depression.

However, now a new study confirms that they can be pretty good for managing substance abuse disorders like AUD.

In a new study published in the journal JAMA, researchers compared the effectiveness of psilocybin with diphenhydramine, a kind of antihistamine with a sedative effect and known to lower cravings. The study found that when combined with psychotherapy, psilocybin is much better and has a long-lasting effect.

Researchers say that what has amazed them is the persistent effect of psilocybin. Though the study was small and had a sample size of only 100, the findings were quite surprising. They found that psilocybin was almost twice more effective compared to diphenhydramine.

In the study, researchers divided participants into two equal groups. Both groups received 12 psychotherapy sessions over 12 weeks. However, one group received two dosages of psilocybin and the other group, diphenhydramine, as a placebo. They tracked the patients for six months.

At the end of the study, they found that just by adding two doses of psilocybin, the effect of psychotherapy increased considerably. Thus, after six months, about 10% still reported drinking heavily. However, these numbers were almost 25% in the diphenhydramine group.

What is impressive is that in the psilocybin group, twice as many participants stopped drinking altogether, 48% vs. 24%. They said that they had reduced cravings for alcohol after a psilocybin treatment. Those who stopped drinking said they did not consider themselves alcoholics anymore.

Researchers then went further and offered a third dose of psilocybin to study participants at the end of the six-month study. They said that after this dosage, many more reported benefits.
Researchers say they are very encouraged by their findings, and study results surpass their expectations. Moreover, psilocybin did not cause any side effects, and yet it had a prolonged benefit.
Researchers say that they are now planning more extensive study. They are planning a 3-year study with more than 200 participants. And they also plan to have participants from diverse backgrounds. Nevertheless, researchers think that psilocybin appears to be a real breakthrough in managing AUD.